A worldwide e-Infrastructure for NMR and structural biology

Andrea Giachetti (CIRMMP)

Contact details
Name: 
Andrea
Surname: 
Giachetti
E-mail address: 
giachetti@cerm.unifi.it
Tel. number: 
+39 0554574244
Company/Institute details
Company/Institute name: 
CIRMMP
Company/Institute description: 

The Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine (CIRMMP) was founded in 1994 among the universities of Florence, Siena and Bologna to develop and coordinate resources in a scientific field of growing interest, the study of metalloproteins and metalloenzymes.

CIRMMP manages and partially owns one of the most well-equipped NMR laboratories in the world: the Centro di Risonanze Magnetiche (CERM). The center is equipped with a 950 MHz, 900 MHz, 850 MHz WB, 800 MHz, 700 MHz WB, 2 x 700 MHz, 2 x 600 MHz, a 500 MHz and a 400 MHz magnet, besides other routine instruments, as well as one relaxometer. Click here to learn more about CERM's instrumentation.

The 500, 700, 800, 900 and 950 MHz magnets are equipped with cryoprobes. Biophysical instrumentation such as absorbtion and CD spectroscopy fluorescence, microcalorimetry, and stopped flow tools are operative at CERM, whereas EPR mass spectroscopy and X-ray facilities are also available in flanking laboratories. CIRMMP also supports protein production with a well-equipped and robotized molecular biology laboratory for high throughput production.

These instruments are tools for structural biology studies in the post-genomic era. Structures of proteins are solved and the relation between their structure and activity is studied, as well as protein-protein recognition and interactions between DNA/RNA and proteins for the investigation of regulation. At CERM, dozens of protein structures in solution have been solved and new methodologies for obtaining such structures are continually being developed.

CIRMMP has provided a service for magnetic resonance at the European level since 1994, and also supports a national service for private and public research institutions through a national scientific committee.

Expertise
Category: 
NMR
Structural Biology
Position: 
Senior scientist
Keywords: 
Molecular Dynamics, NMR structure calculation, Modelling
Number of publications: 
16
Years active: 
2004

Cite WeNMR/WestLife

 
Usage of the WeNMR/WestLife portals should be acknowledged in any publication:
 
"The FP7 WeNMR (project# 261572) and H2020 West-Life (project# 675858) European e-Infrastructure projects are acknowledged for the use of their web portals, which make use of the EGI infrastructure and DIRAC4EGI service with the dedicated support of CESNET-MetaCloud, INFN-PADOVA, NCG-INGRID-PT, RAL-LCG2, TW-NCHC, SURFsara and NIKHEF, and the additional support of the national GRID Initiatives of Belgium, France, Italy, Germany, the Netherlands, Poland, Portugal, Spain, UK, South Africa, Malaysia, Taiwan and the US Open Science Grid."
 
And the following article describing the WeNMR portals should be cited:
Wassenaar et al. (2012). WeNMR: Structural Biology on the Grid.J. Grid. Comp., 10:743-767.

EGI-approved

The WeNMR Virtual Research Community has been the first to be officially recognized by the EGI.

European Union

WeNMR is an e-Infrastructure project funded under the 7th framework of the EU. Contract no. 261572

WestLife, the follow up project of WeNMR is a Virtual Research Environment e-Infrastructure project funded under Horizon 2020. Contract no. 675858

West-Life