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CAPRI 5th evaluation meeting - Utrecht 2013

Event Date: 
Wed, 2013-04-17 (All day) - Fri, 2013-04-19 (All day)

The CAPRI (Critical Assessment of PRedicted Interactions) 5th evaluation meeting will take place in Utrecht on April 17-19, 2013.

Interactomes are large, intricate and highly dynamic molecular networks that determine the fate of the cell. They rely on thousands of protein complexes that form the executive machinery underlying biological processes, from DNA replication to protein degradation through metabolism. To catalyze a wide diversity of chemical processes, proteins get in touch with other proteins, nucleic acids, sugars, lipids, and various other molecules. In today’s post-genomic era, this versatility has been uncovered by studies that have revealed the number and composition of these macromolecular assemblies while others have highlighted the structural and functional aspects of their interactions. Understanding the function of these macromolecular assemblies and designing new drug that target them requires taking the step towards solving their three-dimensional structures.

There is still a large gap between the number of complexes identified by large-scale proteomics efforts and those for which high-resolution 3D experimental structures are available (solved typically by classical X-ray crystallography and NMR). At the same time, methods such as cryo-electron microscopy (cryo-EM) or small angle X-ray scattering (SAXS) are generating a wealth of lower resolution structural information that can complement prediction efforts. Being able to predict, model and understand biomolecular assemblies requires tackling the challenges of predicting large conformational changes potentially occurring upon binding, dealing with heterogeneous multi-component assemblies and predicting their binding affinity. The molecular docking community has already started tackling those challenges and new integrative approaches are emerging.

The 5th CAPRI evaluation meeting will present and discuss the current state of the art in the field. Groups participating in CAPRI, and/or working in the area of (integrative) modelling of biomolecular interactions, are invited to present their most recent achievements. We particularly encourage contributions presenting innovative approaches to the challenges in this field. The program will include a few invited lectures from experimentalists in the structural biology field, regular lectures from groups working in the modelling field and, in addition, a number of short presentations from young researchers who will be selected from abstract submission to encourage their participation to this meeting.

 

Visit for updates the CAPRI2013 web site at: www.capri2013.nl

Cite WeNMR/WestLife

 
Usage of the WeNMR/WestLife portals should be acknowledged in any publication:
 
"The FP7 WeNMR (project# 261572) and H2020 West-Life (project# 675858) European e-Infrastructure projects are acknowledged for the use of their web portals, which make use of the EGI infrastructure and DIRAC4EGI service with the dedicated support of CESNET-MetaCloud, INFN-PADOVA, NCG-INGRID-PT, RAL-LCG2, TW-NCHC, SURFsara and NIKHEF, and the additional support of the national GRID Initiatives of Belgium, France, Italy, Germany, the Netherlands, Poland, Portugal, Spain, UK, South Africa, Malaysia, Taiwan and the US Open Science Grid."
 
And the following article describing the WeNMR portals should be cited:
Wassenaar et al. (2012). WeNMR: Structural Biology on the Grid.J. Grid. Comp., 10:743-767.

EGI-approved

The WeNMR Virtual Research Community has been the first to be officially recognized by the EGI.

European Union

WeNMR is an e-Infrastructure project funded under the 7th framework of the EU. Contract no. 261572

WestLife, the follow up project of WeNMR is a Virtual Research Environment e-Infrastructure project funded under Horizon 2020. Contract no. 675858

West-Life